Autogenous bone is still considered the ââ?¬Å?gold standardââ?¬Â of regenerative and reconstructive procedures involving mandibular defects.\r\nHowever, harvesting of this material can lead to many complications like increasing morbidity, expanding of the surgical time,\r\nand incomplete healing of the donor site. In the last few years many authors looked for the development of effective reconstruction\r\nprocedures using osteoinductive factors without the need for conventional bone grafting. The first-in-human study involving the\r\nuse of BoneMorphongenic Proteins (rhBMP) for mandibular reconstruction was performed in 2001 byMoghadam. Only few articles\r\nhave been reported in the literature since then. The purpose of this study was to search and analyze the literature involving the\r\nuse of rhBMP for reconstruction of mandibular defects. In all the studies reported, authors agree that the use of grown factors may\r\nrepresent the future of regenerative procedures with more research necessary for confirmation.
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